| | |  | | | | Record from Web of Science® | | | | | | |
| AP-1 as a regulator of cell life and death |
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| Author(s): Shaulian E, Karin M |
| Source: NATURE CELL BIOLOGY Volume: 4 Issue: 5 Pages: E131-E136 Published: MAY 2002 |
| Times Cited: 721 References: 98 |
| Abstract: The transcription factor AP-1 ( activator protein-1) is involved in cellular proliferation, transformation and death. Using mice and cells lacking AP-1 components, the target-genes and molecular mechanisms mediating these processes were recently identified. Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators. Mostly, c-Jun is a positive regulator of cell proliferation, whereas JunB has the converse effect. The intricate relationships between the different Jun proteins, their activities and the mechanisms that mediate them will be discussed. |
| Document Type: Review |
| Language: English |
| Reprint Address: Shaulian, E (reprint author), Hebrew Univ Jerusalem, Sch Med, Dept Expt Med & Canc Res, IL-91120 Jerusalem, Israel |
Addresses:
1. Hebrew Univ Jerusalem, Sch Med, Dept Expt Med & Canc Res, IL-91120 Jerusalem, Israel
2. Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 547GR |
| ISSN: 1465-7392 |
| DOI: 10.1038/ncb0502-e131 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |