| | |  | | | | Record from Web of Science® | | | | | | |
| Assessing antidepressant activity in rodents: recent developments and future needs |
|
|
| Author(s): Cryan JF, Markou A, Lucki I |
| Source: TRENDS IN PHARMACOLOGICAL SCIENCES Volume: 23 Issue: 5 Pages: 238-245 Published: MAY 2002 |
| Times Cited: 396 References: 87 |
| Abstract: Animal models are indispensable tools in the search to identify new antidepressant drugs and to provide insights into the neuropathology that underlies the idiopathic disease state of depression. As new targets are developed, both serendipitously and through hypothesis-driven research, existing animal paradigms are being modified and new tests are being developed to detect antidepressant actions of compounds acting on a broad range of neural and genetic targets. This review focuses on recent findings regarding some of the most widely employed animal models used currently to predict antidepressant potential. Emphasis is placed on recent modifications to such paradigms that have increased their utility and reliability. Furthermore, some key issues that need to be addressed for future discovery of novel antidepressant agents are examined, and the available data on genetically altered mice that might lead to the discovery of novel targets for antidepressant action are collated. |
| Document Type: Review |
| Language: English |
| Reprint Address: Cryan, JF (reprint author), Novaratis Pharma AG, Neuromodulat Unit, WSJ 386-344, CH-4002 Basel, Switzerland |
Addresses:
1. Novaratis Pharma AG, Neuromodulat Unit, CH-4002 Basel, Switzerland
2. Scripps Res Inst, Dept Neuropharmacol, La Jolla, CA 92037 USA
3. Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
4. Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA |
| Publisher: ELSEVIER SCIENCE LONDON, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Pharmacology & Pharmacy |
| IDS Number: 547YV |
| ISSN: 0165-6147 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |