| | |  | | | | Record from Web of Science® | | | | | | |
| Critical role for CCA1 and LHY in maintaining circadian rhythmicity in Arabidopsis |
|
|
| Author(s): Alabadi D, Yanovsky MJ, Mas P, Harmer SL, Kay SA |
| Source: CURRENT BIOLOGY Volume: 12 Issue: 9 Pages: 757-761 Published: APR 30 2002 |
| Times Cited: 112 References: 15 |
| Abstract: Circadian clocks are autoregulatory, endogenous mechanisms that allow organisms, from bacteria to humans, to advantageously time a wide range of activities within 24-hr environmental cycles [1]. CIRCADIAN CLOCK ASSOCIATED I (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) are thought to be important components of the circadian clock in the model plant Arabidopsis [2-5]. The similar circadian phenotypes of lines overexpressing either CCA1 or LHY have suggested that the functions of these two transcription factors are largely overlapping. cca1-1 plants, which lack CCA1 protein, show a short-period phenotype for the expression of several genes when assayed under constant light conditions [5]. This suggests that LHY function is able to only partially compensate for the lack of CCA1 protein, resulting in a clock with a faster pace in cca1-1 plants. We have obtained plants lacking CCA1 and with LHY function strongly reduced, cca1-1 lhy-R, and show that these plants are unable to maintain sustained oscillations in both constant light and constant darkness. However, these plants exhibit some circadian function in light/dark cycles, showing that the Arabidopsis circadian clock is not entirely dependent on CCA1 and LHY activities. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kay, SA (reprint author), Scripps Res Inst, Dept Cell Biol, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA |
Addresses:
1. Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
2. Scripps Res Inst, Inst Childhood & Neglected Dis, La Jolla, CA 92037 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE,, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: 548FE |
| ISSN: 0960-9822 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |