| | |  | | | | Record from Web of Science® | | | | | | |
| Telomeres, X-inactivation ratios, and hematopoietic stem cell transplantation in humans: A review |
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| Author(s): Thornley I, Freedman MH |
| Source: STEM CELLS Volume: 20 Issue: 3 Pages: 198-204 Published: 2002 |
| Times Cited: 7 References: 82 |
| Abstract: The marrow repopulating hematopoietic stem cells (HSCs) in an auto- or allograft represent a small fraction of the normal complement of HSCs, yet are required to reconstitute hematopoiesis and sustain it for the lifetime of the recipient. Such a burden imposes a "repticative stress" upon hematopoietic stem/progenitor cells. The finding of accelerated telomere shortening in hematopoietic stem cell transplant (HSCT) recipients raised the specter of accelerated hematopoietic aging. Here, we review the HSCT telomere literature and other studies of surrogate markers of HSC behavior conducted in human HSCT recipients. We present a paradigm for posttransptant hematopoietic reconstitution and speculate on the fate of HSCs in the human transplant setting. |
| Document Type: Review |
| Language: English |
| Reprint Address: Thornley, I (reprint author), Univ Toronto, Hosp Sick Children, Div Hematol Oncol, 555 Univ Ave, Toronto, ON M5G 1X8 Canada |
Addresses:
1. Univ Toronto, Hosp Sick Children, Div Hematol Oncol, Toronto, ON M5G 1X8 Canada |
| Publisher: ALPHAMED PRESS, ONE PRESTIGE PLACE, STE 290, MIAMISBURG, OH 45342-3758 USA |
| Subject Category: Biotechnology & Applied Microbiology; Oncology; Cell Biology; Hematology |
| IDS Number: 551NE |
| ISSN: 1066-5099 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |