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| Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. |
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| Author(s): Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL |
| Source: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM Volume: 87 Issue: 5 Pages: 2391-2394 Published: MAY 2002 |
| Times Cited: 126 References: 26 |
| Abstract: Maintenance of a reduced body weight is associated with decreased 24-hour energy expenditure, and decreased circulating concentrations of leptin and thyroid hormones. To determine whether these adaptive metabolic and endocrine changes are partly leptin-mediated, we measured body composition, aspects of energy expenditure, and circulating concentrations of leptin and thyroid hormones in 4 subjects at 3 time points: 1.) Usual body weight; 2.) While stable at 10% reduced body weight; and 3.) During a 5-week period at 10% reduced body weight while receiving twice per day leptin injections that restored 8AM circulating leptin concentrations to those seen at usual body weight. During maintenance of a 10% reduced body weight circulating T3, T4, and leptin concentrations were decreased. All of these endocrine changes were reversed by administration of "replacement" doses of leptin (r-metHuLeptin). Indirect calorimetry, and subtle changes in body composition associated with leptin administration, were used to calculate the net change in stored calories and in 24-hour energy expenditure, Total energy expenditure increased in all subjects during r-metHuLeptin administration. These data indicate that decrease leptin concentrations resulting from loss of fat mass account for some aspects of the endocrine/metabolic phenotype associated with the weight-reduced state. |
| Document Type: Article |
| Language: English |
| Reprint Address: Rosenbaum, M (reprint author), Columbia Univ, Div Mol Genet, 1150 St Nicholas Ave, New York, NY 10032 USA |
Addresses:
1. Columbia Univ, Div Mol Genet, New York, NY 10032 USA
2. Univ Vermont, Med Ctr, Burlington, VT USA |
| Publisher: ENDOCRINE SOC, 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA |
| Subject Category: Endocrinology & Metabolism |
| IDS Number: 552YP |
| ISSN: 0021-972X |
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