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| Overrepresentation of the short arm of chromosome 12 in seminoma and nonseminoma groups of testicular germ cell tumors |
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| Author(s): Pienkowska-Grela B, Grygalewicz B, Bregula U |
| Source: CANCER GENETICS AND CYTOGENETICS Volume: 134 Issue: 2 Pages: 102-108 Published: APR 15 2002 |
| Times Cited: 7 References: 27 |
| Abstract: The amplification of the short arm of the chromosome 12, especially as the it 12p) marker chromosome, has been found to be a highly nonrandom chromosome abnormality associated with testicular germ cell tumors (TGCT). A series of adult TGCT consisting of seven seminomas (SE) and eight nonseminomas (NS) was analyzed by conventional cytogenetics and fluorescent in situ hybridization. Multiplied chromosome 12 material originating from typical i(12p) and from other markers carrying chromosome 12-derived material was found in almost all analyzed tumors (6 of 7 SE cases and 8 of 8 NS cases). Heterogeneity in the copy number of i(12p) and other 12p-derived markers, as well as chromosome 12 aneuploidy. were higher in NS tumors than in SE. (C) 2002 Elsevier Science Inc. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Pienkowska-Grela, B (reprint author), Maria Sklodowska Curie Mem Canc Ctr, Cytogenet Lab, 5 KW Roentgen Str, PL-02781 Warsaw, Poland |
Addresses:
1. Maria Sklodowska Curie Mem Canc Ctr, Cytogenet Lab, PL-02781 Warsaw, Poland
2. Inst Oncol, PL-02781 Warsaw, Poland |
| Publisher: ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA |
| Subject Category: Oncology; Genetics & Heredity |
| IDS Number: 553VC |
| ISSN: 0165-4608 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |