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| Eales disease - An update |
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| Author(s): Biswas J, Sharma T, Gopal L, Madhavan HN, Sulochana KN, Ramakrishnan S |
| Source: SURVEY OF OPHTHALMOLOGY Volume: 47 Issue: 3 Pages: 197-214 Published: MAY-JUN 2002 |
| Times Cited: 31 References: 194 |
| Abstract: Eales disease, first described by Henry Eales in 1880, remains an enigma. The disease, observed more commonly in the Indian subcontinent than in the rest of the world, occurs in young healthy adult males, initially presenting as retinal periphlebitis and later as retinal ischemia that may lead to vascular alterations and neovascularization. Recurrent vitreous hemorrhage with or Without retinal detachment is the common sequelae. In recent years, immunological, molecular biological, and biochemical Studies hake indicated the role of human leukocyte antigen, retinal autoimmunity, mycobacterium tuberculosis genome, and free radical mediated damage in the etiopathogenesis of this disease. However, its etiology appears to be multifactorial. The management depends on the stage of the disease and consists of medical treatment with oral corticosteroids in the active inflammatory stage and laser photocoagulation in the advanced retinal ischemia and neovascularization stages. The results of vitreoretinal surgery have been found to be satisfactory in case of vitreous hemorrhage with or without retinal detachment. (C) 2002 by Elsevier Science Inc. All rights reserved. |
| Document Type: Review |
| Language: English |
| Reprint Address: Biswas, J (reprint author), Med Res Fdn, 18 Coll Rd, Madras 600006, Tamil Nadu India |
Addresses:
1. Med Res Fdn, Madras 600006, Tamil Nadu India
2. Vis Res Fdn, Madras 600006, Tamil Nadu India |
| Publisher: ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA |
| Subject Category: Ophthalmology |
| IDS Number: 559LG |
| ISSN: 0039-6257 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |