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| The many faces of p75(NTR) |
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| Author(s): Hempstead BL |
| Source: CURRENT OPINION IN NEUROBIOLOGY Volume: 12 Issue: 3 Pages: 260-267 Published: JUN 2002 |
| Times Cited: 136 References: 69 |
| Abstract: The neurotrophins utilize a complex receptor system consisting of Trk receptor tyrosine kinases and the structurally unrelated tumor necrosis factor receptor family member, p75(NTR), to confer diverse and sometimes opposing biological actions. The recent identification of selective ligands for p75(NTR), novel isoforms of this receptor, as well as new signaling partners, suggest that the numerous biological actions of the neurotrophins via p75(NTR) may reflect selectivity of ligand-receptor interactions and intracellular adaptor protein recruitment. |
| Document Type: Article |
| Language: English |
| Reprint Address: Hempstead, BL (reprint author), Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USA |
Addresses:
1. Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USA |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Neurosciences |
| IDS Number: 562CX |
| ISSN: 0959-4388 |
| DOI: 10.1016/S0959-4388(02)00321-5 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |