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| Risk factors for proteinuria in a large, multiracial, Southeast Asian population |
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| Author(s): Ramirez SPB, McClellan W, Port FK, Hsu SIH |
| Source: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Volume: 13 Issue: 7 Pages: 1907-1917 Published: JUL 2002 |
| Times Cited: 54 References: 28 |
| Abstract: The factors associated with proteinuria were examined in a large multiracial Asian population participating in a screening program aimed at the early detection of renal disease. Of 213,873 adults who participated, 189,117 with complete data were included. Malay race, increasing age, both extremes of body mass index (BMI), self-reported family history of kidney disease (FKD), and higher systolic and diastolic BP measurements (even at levels classified as being within the normal range) were independently associated with dipstick-positive proteinuria. The odds ratios (OR) for proteinuria increased progressively with age. There was a J-shaped relationship between BMI and proteinuria (OR of 1.3, 1.00, 1.3, 1.6, and 2.5 for BMI of less than or equal to18.00, 23.00 to 24.99, 25.00 to 27.49, 27.50 to 29.99, and greater than or equal to30.00 kg/m(2), respectively, compared with BMI of 18.01 to 22.99 kg/m(2)). OR for proteinuria according to systolic and diastolic BP were significantly increased beginning at levels of 110 and 90 mmHg, respectively. In addition, the Malay race was associated with a significantly higher OR for proteinuria, compared with the Chinese race (OR of 1.3). Finally, FKD was significantly associated with proteinuria (OR of 1.7), whereas a family history of diabetes mellitus and a family history of hypertension were not. When family histories were analyzed by clustering, isolated FKD remained a significant determinant of proteinuria and the magnitude of the effect was not significantly different from that observed in the presence of a coexisting family history of diabetes mellitus or hypertension. This is the first study to evaluate factors associated with proteinuria in an Asian population. The epidemiologic study of renal disease in this population suggests that risk factors for renal disease might differ significantly among racial groups. |
| Document Type: Article |
| Language: English |
| Reprint Address: Ramirez, SPB (reprint author), Natl Kidney Fdn Singapore, Ctr Prevent & Res, 81 Kim Keat Rd, Singapore 328836, Singapore |
Addresses:
1. Natl Kidney Fdn Singapore, Ctr Prevent & Res, Singapore 328836, Singapore
2. Natl Univ Singapore, Fac Med, Singapore, Singapore
3. Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA USA
4. Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA
5. Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA
6. Genome Inst Singapore, Singapore, Singapore |
| Publisher: LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA |
| Subject Category: Urology & Nephrology |
| IDS Number: 567GM |
| ISSN: 1046-6673 |
| DOI: 10.1097/01.ASN.0000018406.20282.C8 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |