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| Diagnosis of gastrointestinal stromal tumors: A consensus approach |
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| Author(s): Fletcher CDM, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, O'Leary TJ, Remotti H, Rubin BP, Shmookler B, Sobin LH, Weiss SW |
| Source: HUMAN PATHOLOGY Volume: 33 Issue: 5 Pages: 459-465 Published: MAY 2002 |
| Times Cited: 771 References: 38 |
| Abstract: As a result of major recent advances in understanding the biology of gastrointestinal stromal tumors (GISTs), specifically recognition of the central role of activating KIT mutations and associated KIT protein expression in these lesions, and the development of novel and effective therapy for GISTs using the receptor tyrosine kinase inhibitor STI-571, these tumors have become the focus of considerable attention by pathologists, clinicians, and patients. Stromal/mesenchymal tumors of the gastrointestinal tract have long been a source of confusion and controversy with regard to classification, line(s) of differentiation, and prognostication. Characterization of the KIT pathway and its phenotypic implications has helped to resolve some but not all of these issues. Given the now critical role of accurate and reproducible pathologic diagnosis in ensuring appropriate treatment for patients with GIST, the National Institutes of Health convened a GIST workshop in April 2001 with the goal of developing a consensus approach to diagnosis and morphologic prognostication. Key elements of the consensus, as described herein, are the defining role of KIT immunopositivity in diagnosis and a proposed scheme for estimating metastatic risk in these lesions, based on tumor size and mitotic count, recognizing that it is probably unwise to use the definitive term "benign" for any GIST, at least at the present time. |
| Document Type: Article |
| Language: English |
| Reprint Address: Fletcher, CDM (reprint author), Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA |
Addresses:
1. Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
2. Harvard Univ, Sch Med, Boston, MA USA
3. NCI, Canc Diag Program, NIH, Bethesda, MD 20892 USA
4. Oregon Hlth Sci Univ, Dept Pathol, Portland, OR 97201 USA
5. Thomas Jefferson Univ, Dept Pathol, Philadelphia, PA 19107 USA
6. Armed Forces Inst Pathol, Dept Soft Tissue Pathol, Washington, DC 20306 USA
7. Armed Forces Inst Pathol, Dept Cellular Pathol, Washington, DC 20306 USA
8. Armed Forces Inst Pathol, Dept Genet & Gastrointestinal Pathol, Washington, DC 20306 USA
9. Columbia Univ Coll Phys & Surg, Dept Pathol, New York, NY 10032 USA
10. Columbia Univ Coll Phys & Surg, Dept Dermatol, New York, NY 10032 USA
11. Univ Washington, Med Ctr, Dept Pathol, Seattle, WA 98195 USA
12. Suburban Hosp, Dept Pathol, Bethesda, MD USA
13. Emory Univ Hosp, Dept Pathol & Lab Med, Atlanta, GA 30322 USA |
| Publisher: W B SAUNDERS CO, INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA |
| Subject Category: Pathology |
| IDS Number: 567QB |
| ISSN: 0046-8177 |
| DOI: 10.1053/hupa.2002.123545 |
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