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| Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis |
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| Author(s): Chuvpilo S, Jankevics E, Tyrsin D, Akimzhanov A, Moroz D, Jha MK, Luehrmann JS, Santner-Nanan B, Feoktistova E, Konig T, Avots A, Schmitt E, Berberich-Siebelt F, Schimpl A, Serfling E |
| Source: IMMUNITY Volume: 16 Issue: 6 Pages: 881-895 Published: JUN 2002 |
| Times Cited: 66 References: 56 |
| Abstract: Threshold levels of individual NFAT factors appear to be critical for apoptosis induction in effector T cells. In these cells, the short isoform A of NFATc1 is induced to high levels due to the autoregulation of the NFATc1 promoter P1 by NFATs. P1 is located within a CpG island in front of exon 1, represents a DNase I hypersensitive chromatin site, and harbors several sites for binding of inducible transcription factors, including a tandemly arranged NFAT site. A second promoter, P2, before exon 2, is not controlled by NFATs and directs synthesis of the longer NFATc1/B+C isoforms. Contrary to other NFATs, NFATc1/A is unable to promote apoptosis, suggesting that NFATc1/A enhances effector functions without promoting apoptosis of effector T cells. |
| Document Type: Article |
| Language: English |
| Reprint Address: Serfling, E (reprint author), Univ Wurzburg, Inst Pathol, Dept Mol Pathol, D-97080 Wurzburg, Germany |
Addresses:
1. Univ Wurzburg, Inst Pathol, Dept Mol Pathol, D-97080 Wurzburg, Germany
2. Univ Wurzburg, Inst Virol & Immunobiol, D-97080 Wurzburg, Germany
3. Univ Mainz, Inst Immunol, D-55101 Mainz, Germany
4. Latvian State Univ, Biomed Res & Study Ctr, LV-1067 Riga, Latvia |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE,, CAMBRIDGE, MA 02138 USA |
| Subject Category: Immunology |
| IDS Number: 568GL |
| ISSN: 1074-7613 |
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