| | |  | | | | Record from Web of Science® | | | | | | |
| Cells as vehicles for cancer gene therapy: The missing link between targeted vectors and systemic delivery? |
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| Author(s): Harrington K, Alvarez-Vallina L, Crittenden M, Gough M, Chong H, Diaz RM, Vassaux G, Lemoine N, Vile R |
| Source: HUMAN GENE THERAPY Volume: 13 Issue: 11 Pages: 1263-1280 Published: JUL 2002 |
| Times Cited: 40 References: 167 |
| Abstract: Systemic administration of currently manufactured viral stocks has not so far achieved sufficient circulating titers to allow therapeutic targeting of metastatic disease. This is due to low initial viral titers, immune inactivation, nonspecific adhesion, and loss of particles. One way to exploit the elegant molecular manipulations that have been made to increase vector targeting is to protect these vectors until they reach the local sites of tumor growth. Various cell types home preferentially to tumors and can be loaded with the constructs required to produce targeted vectors. Here we discuss the potential of using such cell carriers to chaperone precious vectors directly to the tumors. The vectors can incorporate mechanisms to achieve tumor site-inducible expression, along with tumor cell-specific expression of the therapeutic gene and/or replicating viral genomes that would be released at the tumor. In this way, the great advances that have so far been made with the engineering of vector tropisms might be genuinely exploited and converted into clinical benefit. |
| Document Type: Review |
| Language: English |
| Reprint Address: Vile, R (reprint author), Mayo Clin & Mayo Fdn, Program Mol Med, Guggenheim 18,200 1st St SW, Rochester, MN 55905 USA |
Addresses:
1. Mayo Clin & Mayo Fdn, Program Mol Med, Rochester, MN 55905 USA
2. Hosp Univ Clin Puerta de Hierro, Dept Immunol, Madrid, Spain
3. Hammersmith Hosp, Imperial Coll Sch Med, ICRF Mol Oncol Unit, London W12 0HS, England
4. Inst Canc Res, Chester Beatty Labs, Ctr Cell & Mol Biol, Canc Res Campaign, London SW3 6JB, England |
| Publisher: MARY ANN LIEBERT INC PUBL, 2 MADISON AVENUE, LARCHMONT, NY 10538 USA |
| Subject Category: Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental |
| IDS Number: 576QE |
| ISSN: 1043-0342 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |