| | |  | | | | Record from Web of Science® | | | | | | |
| Prediction of plant microRNA targets |
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| Author(s): Rhoades MW, Reinhart BJ, Lim LP, Burge CB, Bartel B, Bartel DP |
| Source: CELL Volume: 110 Issue: 4 Pages: 513-520 Published: AUG 23 2002 |
| Times Cited: 521 References: 49 |
| Abstract: We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterning or cell differentiation. The near-perfect complementarity between plant miRNAs and their targets suggests that many plant miRNAs act similarly to small interfering RNAs and direct mRNA cleavage. The targeting of developmental transcription factors suggests that many plant miRNAs function during cellular differentiation to clear key regulatory transcripts from daughter cell lineages. |
| Document Type: Article |
| Language: English |
| Reprint Address: Bartel, B (reprint author), Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA |
Addresses:
1. Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
2. MIT, Dept Biol, Cambridge, MA 02139 USA
3. Rice Univ, Dept Biochem & Cell Biol, Houston, TX 77005 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 587QJ |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |