| | |  | | | | Record from Web of Science® | | | | | | |
| Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect |
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| Author(s): Farag SS, Fehniger TA, Ruggeri L, Velardi A, Caligiuri MA |
| Source: BLOOD Volume: 100 Issue: 6 Pages: 1935-1947 Published: SEP 15 2002 |
| Times Cited: 207 References: 134 |
| Abstract: Natural killer (NK) cells have held great promise for the immunotherapy of cancer for more than 3 decades' However, to date only modest clinical success has been achieved manipulating the NK cell compartment in patients with malignant disease. Progress in the field of NK cell receptors has revolutionized our concept of how NK cells selectively recognize and lyse tumor and virally infected cells while sparing normal cells. Major families of cell surface receptors that inhibit and activate NK cells to lyse target cells have been characterized, including killer cell immunoglobulinlike receptors (KIRs), C-type lectins, and natural cytotoxicity receptors (NCRs). Further, identification of NK receptor ligands and their expression on normal and transformed cells completes the information needed to begin development of rational clinical approaches to manipulating receptor/ligand interactions for clinical benefit. Indeed, clinical data suggest that mismatch of NK receptors and ligands during allogeneic bone marrow transplantation may be used to prevent leukemia relapse. Here, we review how INK cell receptors control natural cytotoxicity and novel approaches to manipulating NK receptor-ligand interactions for the potential benefit of patients with cancer. |
| Document Type: Review |
| Language: English |
| Reprint Address: Farag, SS (reprint author), Ohio State Univ, Dept Internal Med, Div Hematol Oncol, A433A Starling Loving Hall,320 W 10th Ave, Columbus, OH 43210 USA |
Addresses:
1. Ohio State Univ, Dept Internal Med, Div Hematol Oncol, Columbus, OH 43210 USA
2. Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
3. Univ Perugia, Dept Clin & Expt Med, I-06100 Perugia, Italy
4. Univ Perugia, Div Hematol & Clin Immunol, I-06100 Perugia, Italy |
| Publisher: AMER SOC HEMATOLOGY, 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA |
| Subject Category: Hematology |
| IDS Number: 591MT |
| ISSN: 0006-4971 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |