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| Microglia as liaisons between the immune and central nervous systems: Functional implications for multiple sclerosis |
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| Author(s): Carson MJ |
| Source: GLIA Volume: 40 Issue: 2 Pages: 218-231 Published: NOV 2002 |
| Times Cited: 91 References: 112 |
| Abstract: Multiple sclerosis is a chronic demyelinating inflammatory disease of the central nervous system (CNS). As the tissue macrophage of the CNS, microglia have the potential to regulate and be regulated by cells of the CNS and by CNS-infiltrating immune cells. The exquisite sensitivity of microglia to these signals, coupled with their ability to develop a broad range of effector functions, allows the CNS to tailor microglial function for specific physiological needs. However, the great plasticity of microglial responses can also predispose these cells to amplify disproportionately the irrelevant or dysfunctional signals provided by either the CNS or immune systems. The consequences of such an event could be the conversion of self-limiting inflammatory responses into chronic neurodegeneration and may explain in part the heterogeneous nature of multiple sclerosis. (C) 2002 Wiley-Liss, Inc. |
| Document Type: Review |
| Language: English |
| Reprint Address: Carson, MJ (reprint author), Scripps Res Inst, Dept Mol Biol, 10550 N Torrey Pines Rd,MB10, La Jolla, CA 92037 USA |
Addresses:
1. Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA |
| Subject Category: Neurosciences |
| IDS Number: 611BA |
| ISSN: 0894-1491 |
| DOI: 10.1002/glia.10145 |
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