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| Limbic-striatal memory systems and drug addiction |
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| Author(s): Robbins TW, Everitt J |
| Source: NEUROBIOLOGY OF LEARNING AND MEMORY Volume: 78 Issue: 3 Pages: 625-636 Published: NOV 2002 |
| Times Cited: 131 References: 33 |
| Abstract: Drug addiction can be understood as a pathological subversion of normal brain learning and memory processes strengthened by the motivational impact of drug-associated stimuli, leading to the establishment of compulsive drug-seeking habits. Such habits evolve through a cascade of complex associative processes with Pavlovian and instrumental components that may depend on the integration and coordination of output from several somewhat independent neural systems of learning and memory, each contributing to behavioral performance. Data are reviewed that help to define the influences of conditioned Pavlovian stimuli on goal-directed behavior via sign-tracking, motivational arousal, and conditioned reinforcement. Such influences are mediated via defined corticolimbic-striatal systems converging on the ventral striatum and driving habit-based learning that may depend on the dorsal striatum. These systems include separate and overlapping influences from the amygdala, hippocampus, and cingulate and medial prefrontal cortex on drug-seeking as well as drug-taking behavior, including the propensity to relapse. (C) 2002 Elsevier Science (USA). |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: Robbins, TW (reprint author), Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England |
Addresses:
1. Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England |
| Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA |
| Subject Category: Behavioral Sciences; Neurosciences; Psychology; Psychology, Multidisciplinary |
| IDS Number: 620HL |
| ISSN: 1074-7427 |
| DOI: 10.1006/nlme.2002.4103 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |