| | |  | | | | Record from Web of Science® | | | | | | |
| Guidance of primordial germ cell migration by the chemokine SDF-1 |
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| Author(s): Doitsidou M, Reichman-Fried M, Stebler J, Koprunner M, Dorries J, Meyer D, Esguerra CV, Leung T, Raz E |
| Source: CELL Volume: 111 Issue: 5 Pages: 647-659 Published: NOV 27 2002 |
| Times Cited: 190 References: 74 |
| Abstract: The signals directing primordial germ cell (PGC) migration in vertebrates are largely unknown. We demonstrate that sdf-1 mRNA is expressed in locations where PGCs are found and toward which they migrate in wild-type as well as in mutant embryos in which PGC migration is abnormal. Knocking down SDF-1 or its receptor CXCR4 results in severe defects in PGC migration. Specifically, PGCs that do not receive the SDF-1 signal exhibit lack of directional movement toward their target and arrive at ectopic positions within the embryo. Finally, we show that the PGCs can be attracted toward an ectopic source of the chemokine, strongly suggesting that this molecule provides a key directional cue for the PGCs. |
| Document Type: Article |
| Language: English |
| Reprint Address: Raz, E (reprint author), Max Planck Inst Biophys Chem, Fassberg 11, D-37077 Gottingen, Germany |
Addresses:
1. Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany
2. Univ Freiburg, Inst Biol 1, Dept Dev Biol, D-79104 Freiburg, Germany
3. Mermaid Pharmaceut GmbH, D-20251 Hamburg, Germany |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 621MV |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |