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Initial sequencing and comparative analysis of the mouse genome
Author(s): Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Bork P, Botcherby M, Bray N, Brent MR, Brown DG, Brown SD, Bult C, Burton J, Butler J, Campbell RD, Carninci P, Cawley S, Chiaromonte F, Chinwalla AT, Church DM, Clamp M, Clee C, Collins FS, Cook LL, Copley RR, Coulson A, Couronne O, Cuff J, Curwen V, Cutts T, Daly M, David R, Davies J, Delehaunty KD, Deri J, Dermitzakis ET, Dewey C, Dickens NJ, Diekhans M, Dodge S, Dubchak I, Dunn DM, Eddy SR, Elnitski L, Emes RD, Eswara P, Eyras E, Felsenfeld A, Fewell GA, Flicek P, Foley K, Frankel WN, Fulton LA, Fulton RS, Furey TS, Gage D, Gibbs RA, Glusman G, Gnerre S, Goldman N, Goodstadt L, Grafham D, Graves TA, Green ED, Gregory S, Guigo R, Guyer M, Hardison RC, Haussler D, Hayashizaki Y, Hillier LW, Hinrichs A, Hlavina W, Holzer T, Hsu F, Hua A, Hubbard T, Hunt A, Jackson I, Jaffe DB, Johnson LS, Jones M, Jones TA, Joy A, Kamal M, Karlsson EK, Karolchik D, Kasprzyk A, Kawai J, Keibler E, Kells C, Kent WJ, Kirby A, Kolbe DL, Korf I, Kucherlapati RS, Kulbokas EJ, Kulp D, Landers T, Leger JP, Leonard S, Letunic I, Levine R, Li J, Li M, Lloyd C, Lucas S, Ma B, Maglott DR, Mardis ER, Matthews L, Mauceli E, Mayer JH, McCarthy M, McCombie WR, McLaren S, McLay K, McPherson JD, Meldrim J, Meredith B, Mesirov JP, Miller W, Miner TL, Mongin E, Montgomery KT, Morgan M, Mott R, Mullikin JC, Muzny DM, Nash WE, Nelson JO, Nhan MN, Nicol R, Ning Z, Nusbaum C, O'Connor MJ, Okazaki Y, Oliver K, Larty EO, Pachter L, Parra G, Pepin KH, Peterson J, Pevzner P, Plumb R, Pohl CS, Poliakov A, Ponce TC, Ponting CP, Potter S, Quail M, Reymond A, Roe BA, Roskin KM, Rubin EM, Rust AG, Santos R, Sapojnikov V, Schultz B, Schultz J, Schwartz MS, Schwartz S, Scott C, Seaman S, Searle S, Sharpe T, Sheridan A, Shownkeen R, Sims S, Singer JB, Slater G, Smit A, Smith DR, Spencer B, Stabenau A, Strange-Thomann NS, Sugnet C, Suyama M, Tesler G, Thompson J, Torrents D, Trevaskis E, Tromp J, Ucla C, Vidal AU, Vinson JP, von Niederhausern AC, Wade CM, Wall M, Weber RJ, Weiss RB, Wendl MC, West AP, Wetterstrand K, Wheeler R, Whelan S, Wierzbowski J, Willey D, Williams S, Wilson RK, Winter E, Worley KC, Wyman D, Yang S, Yang SP, Zdobnov EM, Zody MC, Lander ES
Source: NATURE    Volume: 420    Issue: 6915    Pages: 520-562    Published: DEC 5 2002  
Times Cited: 2,482     References: 331     
Abstract: The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.
Document Type: Review
Language: English
Reprint Address: Waterston, RH (reprint author), Washington Univ, Sch Med, Genome Sequencing Ctr, Campus Box 8501,4444 Forest Pk Ave, St Louis, MO 63108 USA
Addresses:
1. Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
2. MIT, Ctr Genome Res, Whitehead Inst, Cambridge, MA 02141 USA
3. European Bioinformat Inst, Cambridge CB10 1SD, England
4. Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England
5. Univ Pompeu Fabra, Inst Municipal Invest Med, Res Grp Biomed Informat, Barcelona, Catalonia Spain
6. GlaxoSmithKline Inc, King Of Prussia, PA 19406 USA
7. NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20892 USA
8. Univ Calif Berkeley, Dept Math, Berkeley, CA 94720 USA
9. Univ Geneva, Sch Med, Div Med Genet, CH-1211 Geneva 10, Switzerland
10. Univ Calif Santa Cruz, Ctr Biomol Sci & Engn, Santa Cruz, CA 95064 USA
11. European Mol Biol Lab, D-69117 Heidelberg, Germany
12. MRC, Mammalian Genet Unit, UK MRC Mouse Sequencing Consortium, Harwell OX11 0RD, Berks England
13. Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA
14. Washington Univ, Dept Comp Sci, St Louis, MO 63130 USA
15. Univ Waterloo, Sch Comp Sci, Waterloo, ON N2L 3G1 Canada
16. Jackson Lab, Bar Harbor, ME 04609 USA
17. Yokohama Inst, RIKEN Genom Sci Ctr, Lab Genome Explorat, Kanagawa 2300045, Japan
18. Affymetrix Inc, Oakland, CA 94608 USA
19. Penn State Univ, Dept Stat, University Pk, PA 16802 USA
20. Penn State Univ, Dept Hlth Evaluat Sci, University Pk, PA 16802 USA
21. NHGRI, NIH, Bethesda, MD 20892 USA
22. Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
23. Univ Calif Berkeley, Dept Elect Engn, Berkeley, CA 94720 USA
24. Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England
25. Univ Utah, Dept Human Genet, Salt Lake City, UT 84112 USA
26. Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA
27. Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
28. Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
29. Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA
30. Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA
31. Inst Syst Biol, Seattle, WA 98103 USA
32. NHGRI, NIH, Bethesda, MD 20892 USA
33. Univ Calif Santa Cruz, Howard Hughes Med Inst, Santa Cruz, CA 95064 USA
34. Univ Oklahoma, Dept Chem & Biochem, Adv Ctr Genome Technol, Norman, OK 73019 USA
35. Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
36. Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
37. Harvard Univ, Sch Med, Harvard Partners Ctr Genet & Genom, Boston, MA 02115 USA
38. Penn State Univ, Dept Stat, University Pk, PA 16802 USA
39. Univ Calif Santa Barbara, Dept Comp Sci, Santa Barbara, CA 93106 USA
40. US DOE, Joint Genome Inst, Walnut Creek, CA 94598 USA
41. Univ Western Ontario, Dept Comp Sci, London, ON N6A 5B7 Canada
42. Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
43. Wellcome Trust Res Labs, London NW1 2BE, England
44. Univ Calif San Diego, Dept Comp Sci & Engn, La Jolla, CA 92093 USA
45. Max Planck Inst Mol Genet, D-14195 Berlin, Germany
46. Genome Therapeut Corp, Waltham, MA 02453 USA
47. Bioinformat Solut Inc, Waterloo, ON N2L 3L2 Canada
48. Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
49. MIT, Dept Biol, Cambridge, MA 02138 USA
Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Subject Category: Multidisciplinary Sciences
IDS Number: 621VK
ISSN: 0028-0836
DOI: 10.1038/nature01262
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