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| Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates |
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| Author(s): Champoux M, Bennett A, Shannon C, Higley JD, Lesch KP, Suomi SJ |
| Source: MOLECULAR PSYCHIATRY Volume: 7 Issue: 10 Pages: 1058-1063 Published: 2002 |
| Times Cited: 113 References: 27 |
| Abstract: A polymorphism in the serotonin (5-HT) transporter gene regulatory region (5-HTTLPR) is associated with measures of 5-HT transporter (5-HTT) expression and 5-HT-mediated behaviors in humans. An analogous length variation of the 5-HTTLPR has been reported in rhesus monkeys (rh5-HTTLPR). A retrospective association study was conducted on 115 rhesus macaque infants either homozygous for the long 5HTTLPR variant (I/I) or heterozygous for the short and long form (I/s). To assess contributions of genotype and early rearing environment, 36 mother-reared monkeys (I/I = 26, I/s = 10) and 79 nursery-reared monkeys (I/I = 54, I/s = 25) were assessed on days 7, 14, 21, and 30 of life on a standardized primate neurobehavioral test designed to measure orienting, motor maturity, reflex functioning, and temperament. Both mother-reared and nursery-reared heterozygote animals demonstrated increased affective responding relative to I/I homozygotes. Nursery-reared, but not mother-reared, IN infants exhibited lower orientation scores than their I/I counterparts. These results demonstrate the contributions of rearing environment and genetic background, and their interaction, in a nonhuman primate model of behavioral development. |
| Document Type: Article |
| Language: English |
| Reprint Address: Champoux, M (reprint author), NICHHD, Lab Comparat Ethl, Anim Ctr, NIH, POB 529, Poolesville, MD 20837 USA |
Addresses:
1. NICHHD, Lab Comparat Ethl, Anim Ctr, NIH, Poolesville, MD 20837 USA
2. NIAAA, Clin Studies Lab, Primate Unit, Anim Ctr,NIH, Poolesville, MD USA
3. Univ Wurzburg, Dept Psychiat & Psychotherapy, Wurzburg, Germany |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology; Neurosciences; Psychiatry |
| IDS Number: 623EC |
| ISSN: 1359-4184 |
| DOI: 10.1038/sj.mp.4001157 |
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