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| Natural history of human immunodeficiency virus disease in southern India |
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| Author(s): Kumarasamy N, Solomon S, Flanigan TP, Hemalatha R, Thyagarajan SP, Mayer KH |
| Source: CLINICAL INFECTIOUS DISEASES Volume: 36 Issue: 1 Pages: 79-85 Published: JAN 1 2003 |
| Times Cited: 58 References: 38 |
| Abstract: There are few reports of the natural history of human immunodeficiency virus (HIV) infection from Asia. In a retrospective analysis of 594 patients (72.9% male; baseline CD4 cell count, 216 cells/muL) receiving care at YRG Center for AIDS Research and Education, a tertiary HIV referral center in southern India, the mean duration of survival from serodiagnosis was 92 months. Ninety-three percent of the patients acquired infection through heterosexual contact. The most common acquired immune deficiency syndrome-defining illnesses were pulmonary tuberculosis (49%; median duration of survival, 45 months), Pneumocystis carinii pneumonia (6%; median duration of survival, 24 months), cryptococcal meningitis (5%; median duration of survival, 22 months), and central nervous system toxoplasmosis (3%; median duration of survival, 28 months). Persons with a CD4 lymphocyte count of <200 cells/μL were 19 times (95% confidence interval [CI], 5.56-64.77) more likely to die than were those with CD4 cell count of >350 cells/muL. Patients who had greater than or equal to1 opportunistic infection were 2.6 times more likely to die (95% CI, 0.95-7.09) than were those who did not have an opportunistic infection. Antiretroviral therapy for patients with low CD4 lymphocyte counts improved the odds of survival (odds ratio, 5.37; 95% CI, 1.82-15.83). |
| Document Type: Article |
| Language: English |
| Reprint Address: Kumarasamy, N (reprint author), YRG Ctr AIDS Res & Educ, 1 Raman St, T Nagar 600017, Chennai India |
Addresses:
1. YRG Ctr AIDS Res & Educ, T Nagar 600017, Chennai India
2. Univ Madras, Dr ALM Post Grad Inst Basic Med Sci, Dept Microbiol, Chennai, India
3. Brown Univ, Miriam Hosp, Providence, RI USA |
| Publisher: UNIV CHICAGO PRESS, 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA |
| Subject Category: Immunology; Infectious Diseases; Microbiology |
| IDS Number: 627DM |
| ISSN: 1058-4838 |
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