| Pancreatic-hepatic switches in vivo |
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| Author(s): Grompe M |
| Source: MECHANISMS OF DEVELOPMENT Volume: 120 Issue: 1 Pages: 99-106 Published: JAN 2003 |
| Times Cited: 32 References: 63 |
| Abstract: The existence of a common endodermal progenitor cell to both pancreas and liver is suggested by anatomy of the development of pancreatic and liver buds in embryogenesis. Here we review the large body of evidence that pancreas to liver and liver to pancreas cell differentiation can also occur in adult life. The published data are consistent with the hypothesis that endodermal progenitor cells, capable of giving rise to multiple hepatic and pancreatic cell types continue to persist. These cells may represent a stem cell reservoir with potential in cell therapy applications in the future. (C) 2002 Published by Elsevier Science Ireland Ltd. |
| Document Type: Review |
| Language: English |
| Reprint Address: Grompe, M (reprint author), Oregon Hlth Sci Univ, Dept Med & Mol Genet L103, 3181 SW Sam Jackson Pk Rd, Portland, OR 97201 USA |
Addresses:
1. Oregon Hlth Sci Univ, Dept Med & Mol Genet L103, Portland, OR 97201 USA |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Developmental Biology |
| IDS Number: 635VX |
| ISSN: 0925-4773 |