| | |  | | | | Record from Web of Science® | | | | | | |
| Chemokines: Agents for the immunotherapy of cancer? |
|
|
| Author(s): Homey B, Muller A, Zlotnik A |
| Source: NATURE REVIEWS IMMUNOLOGY Volume: 2 Issue: 3 Pages: 175-184 Published: MAR 2002 |
| Times Cited: 168 References: 86 |
| Abstract: Chemokines, a superfamilly of small cytokine-like molecules, regulate leukocyte transport in the body. In recent years, we have witnessed the transition of immunotherapeutic strategies from the laboratory to the bedside. Here, we review the role of chemokines in tumour biology and the development of the host's anti-tumour defence. We summarize the current knowledge of chemokine-receptor expression by relevant cellular components of the immune system and the role of their ligands in the organization of the antitumour immune response. Finally, we discuss recent findings which indicate that chemokines have therapeutic potential as adjuvants or treatments in antitumour immunotherapy, as well as remaining questions and perspectives for translating experimental evidence into clinical practice. |
| Document Type: Review |
| Language: English |
| Reprint Address: Homey, B (reprint author), Univ Dusseldorf, Dept Dermatol, D-40225 Dusseldorf, Germany |
Addresses:
1. Univ Dusseldorf, Dept Dermatol, D-40225 Dusseldorf, Germany
2. Univ Dusseldorf, Dept Radiat Oncol, D-40225 Dusseldorf, Germany
3. Eos Biotechnol, San Francisco, CA 94080 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Immunology |
| IDS Number: 636CZ |
| ISSN: 1474-1733 |
| DOI: 10.1038/nri748 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |