| | |  | | | | Record from Web of Science® | | | | | | |
| Cytotoxic T lymphocytes: All roads lead to death |
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| Author(s): Barry M, Bleackley RC |
| Source: NATURE REVIEWS IMMUNOLOGY Volume: 2 Issue: 6 Pages: 401-409 Published: JUN 2002 |
| Times Cited: 252 References: 110 |
| Abstract: Cytotoxic T lymphocytes (CTLs) provide potent defences against virus infection and intracellular pathogens. However, CTLs have a dark side - their lytic machinery can be directed against self-tissues in autoimmune disorders, transplanted cells during graft rejection and host tissues to cause graft-versus-host disease, which is one of the most serious diseases related to CTL function. Although this duplicitous behaviour might seem contradictory, both beneficial and detrimental effects are the result of the same effector proteins. So, an understanding of the mechanisms that are used by CTLs to destroy targets and a knowledge of pathogen immune-evasion strategies will provide vital information for the design of new therapies. |
| Document Type: Review |
| Language: English |
| Reprint Address: Barry, M (reprint author), Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2H7 Canada |
Addresses:
1. Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2H7 Canada
2. Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7 Canada |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Immunology |
| IDS Number: 636DE |
| ISSN: 1474-1733 |
| DOI: 10.1038/nri819 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |