| | |  | | | | Record from Web of Science® | | | | | | |
| A blast from the past: Clearance of apoptotic cells regulates immune responses |
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| Author(s): Savill J, Dransfield I, Gregory C, Haslett C |
| Source: NATURE REVIEWS IMMUNOLOGY Volume: 2 Issue: 12 Pages: 965-975 Published: DEC 2002 |
| Times Cited: 540 References: 125 |
| Abstract: Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of dying cells by monocytes/macrophages and dendritic cells can also influence immune responses markedly by enhancing or suppressing inflammation. Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future. |
| Document Type: Review |
| Language: English |
| Reprint Address: Savill, J (reprint author), Univ Edinburgh, Royal Infirm, MRC, Ctr Inflammat Res,Dept Clin & Surg Sci Internal M, Lauriston Pl, Edinburgh EH3 9YW, Midlothian Scotland |
Addresses:
1. Univ Edinburgh, Royal Infirm, MRC, Ctr Inflammat Res,Dept Clin & Surg Sci Internal M, Edinburgh EH3 9YW, Midlothian Scotland
2. Univ Edinburgh, Royal Infirm, MRC, Ctr Inflammat Res,Dept Med & Radiol Sci Resp Med, Edinburgh EH3 9YW, Midlothian Scotland |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Immunology |
| IDS Number: 636DT |
| ISSN: 1474-1733 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |