| | |  | | | | Record from Web of Science® | | | | | | |
| Modelling the molecular circuitry of cancer |
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| Author(s): Hahn WC, Weinberg RA |
| Source: NATURE REVIEWS CANCER Volume: 2 Issue: 5 Pages: 331-341 Published: MAY 2002 |
| Times Cited: 390 References: 157 |
| Abstract: Cancer arises from a stepwise accumulation of genetic changes that liberates neoplastic cells from the homeostatic mechanisms that govern normal cell proliferation. In humans, at least four to six mutations are required to reach this state, but fewer seem to be required in mice. By rationalizing the shared and unique elements of human and mouse models of cancer, we should be able to identify the molecular circuits that function differently in humans and mice, and use this knowledge to improve existing models of cancer. |
| Document Type: Review |
| Language: English |
| Reprint Address: Hahn, WC (reprint author), Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA |
Addresses:
1. Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
2. Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Adult Oncol, Dept Med, Boston, MA 02115 USA
3. MIT, Dept Biol, Cambridge, MA 02139 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Oncology |
| IDS Number: 636GQ |
| ISSN: 1474-175X |
| DOI: 10.1038/nrc795 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |