| | |  | | | | Record from Web of Science® | | | | | | |
| NALPs: A novel protein family involved in inflammation |
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| Author(s): Tschopp J, Martinon F, Burns K |
| Source: NATURE REVIEWS MOLECULAR CELL BIOLOGY Volume: 4 Issue: 2 Pages: 95-104 Published: FEB 2003 |
| Times Cited: 251 References: 94 |
| Abstract: A newly discovered family of cytoplasmic proteins-the NALPs-has been implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-inflammatory caspases. |
| Document Type: Review |
| Language: English |
| Reprint Address: Tschopp, J (reprint author), Univ Lausanne, Inst Biochem, BIL, Biomed Res Ctr, Chemin Boveresses 155, CH-1066 Epalinges, Switzerland |
Addresses:
1. Univ Lausanne, Inst Biochem, BIL, Biomed Res Ctr, CH-1066 Epalinges, Switzerland |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 642KG |
| ISSN: 1471-0072 |
| DOI: 10.1038/nrm1019 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |