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| Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement - a survey of 12 517 subjects |
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| Author(s): Tomiyama H, Yamashina A, Arai T, Hirose K, Koji Y, Chikamori T, Hori S, Yamamoto Y, Doba N, Hinohara S |
| Source: ATHEROSCLEROSIS Volume: 166 Issue: 2 Pages: 303-309 Published: FEB 2003 |
| Times Cited: 138 References: 31 |
| Abstract: The present study was conducted to evaluate the influences of age and gender on the results of noninvasive brachial-ankle pulse wave velocity (baPWV). In 12 517 subjects who had no medication and no history of cardiovascular diseases, multiple regression analysis demonstrated that age, blood pressure, body mass index, triglycerides, blood glucose, and uric acid were significant variables for baPWV in both genders. From this population, we extracted 7881 'healthy subjects' (4488 males and 3393 females, 2587 years) without any of the atherogenic risk factors, and the results of baPWV were analyzed chronologically in 5-year age intervals. baPWV was lower in females than in males until age 60, and became similar in both genders over age 60. Multiple regression analysis demonstrated that not only the value of R-2 but also the coefficient of the effect of age on baPWV are larger in females than in males. In the estimation of the regression curve, the relationship between age and baPWV demonstrated a quadratic curve in both genders. Thus, aging influences baPWV, and its effect is more prominent in female. Menopause seems to be the crucial phenomenon to explain the augmented increase in arterial stiffness with aging in females. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Yamashina, A (reprint author), Tokyo Med Univ, Dept Internal Med 2, Shinjuku Ku, 6-7-1,Nishi Shinjuku, Tokyo 1600023, Japan |
Addresses:
1. Tokyo Med Univ, Dept Internal Med 2, Shinjuku Ku, Tokyo 1600023, Japan
2. St Lukes Int Hop, Prevent Med Ctr, Tokyo, Japan
3. Kajima corp, Hlth Care Ctr, Tokyo, Japan
4. Life Planning Ctr, Tokyo, Japan |
| Publisher: ELSEVIER SCI IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND |
| Subject Category: Peripheral Vascular Disease |
| IDS Number: 644CZ |
| ISSN: 0021-9150 |
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