| | |  | | | | Record from Web of Science® | | | | | | |
| You Wnt some, you lose some: oncogenes in the Wnt signaling pathway |
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| Author(s): van Es JH, Barker N, Clevers H |
| Source: CURRENT OPINION IN GENETICS & DEVELOPMENT Volume: 13 Issue: 1 Pages: 28-33 Published: FEB 2003 |
| Times Cited: 68 References: 50 |
| Abstract: The highly regulated Wnt signaling cascade plays a decisive role during embryonic patterning and cell-fate determination. The inappropriate expression of Writ target genes, resulting from deregulation of this pathway, is also implicated in tumorigenesis. Thus, regulation of this pathway is of paramount importance. The Writ signals are extracellularly regulated by a diverse group of antagonists, cofactors; and coreceptors. In the cytoplasm, beta-catenin, a key effector of the Writ signaling cascade, is highly regulated by a large and fascinating complex of proteins. In the nucleus, activation of target genes is regulated by a complex interplay of activators, repressors and other proteins. Recently, new factors in this pathway have been identified and the interplay and mechanisms of action of key players have been better characterized. Collectively, this represents an important step forward in our understanding of the role of Writ signaling in development and oncogenesis. |
| Document Type: Review |
| Language: English |
| Reprint Address: van Es, JH (reprint author), Netherlands Inst Dev Biol, Hubrecht Lab, Uppsalalaan 8, NL-3584 CT Utrecht, Netherlands |
Addresses:
1. Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Cell Biology; Genetics & Heredity |
| IDS Number: 645BR |
| ISSN: 0959-437X |
| DOI: 10.1016/S0959-437X(02)00012-6 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |