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| Research philosopy - Whose hypothesis? Ciphering, sectorials, D lesions, freckles and the operation of Stigler's law |
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| Author(s): Kern SE |
| Source: CANCER BIOLOGY & THERAPY Volume: 1 Issue: 5 Pages: 571-581 Published: SEP-OCT 2002 |
| Times Cited: 5 References: 72 |
| Abstract: Common references to the famous two-hit hypothesis of tumorigenesis are pervasively erroneous, and the recited tenets of this model vary enormously. Exploration of the history of this model reveals a rich philosophical progression that profited from perceptive observations, clever musings, and invesigators clever musings; and rediscoveries by many investigators over a period of decades. The current work is intended to raise the appreciation for this rich history and to address some of the more common errors. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kern, SE (reprint author), Johns Hopkins Univ, Sch Med, 451 Canc Res Bldg,1650 Orleans St, Baltimore, MD 21231 USA |
Addresses:
1. Johns Hopkins Univ, Sch Med, Baltimore, MD 21231 USA |
| Publisher: LANDES BIOSCIENCE, 810 SOUTH CHURCH STREET, GEORGETOWN, TX 78626 USA |
| Subject Category: Oncology |
| IDS Number: 645TY |
| ISSN: 1538-4047 |
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| |  |  |  |  | | | | Record from Web of Science® | |  |  | | | | | | |