| | |  | | | | Record from Web of Science® | | | | | | |
| Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons |
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| Author(s): Saal D, Dong Y, Bonci A, Malenka RC |
| Source: NEURON Volume: 37 Issue: 4 Pages: 577-582 Published: FEB 20 2003 |
| Times Cited: 281 References: 36 |
| Abstract: Drug seeking and drug self-administration in both animals and humans can be triggered by drugs of abuse themselves or by stressful events. Here, we demonstrate that in vivo administration of drugs of abuse with different molecular mechanisms of action as well as acute stress both increase strength at excitatory synapses on midbrain dopamine neurons. Psychoactive drugs with minimal abuse potential do not cause this change. The synaptic effects of stress, but not of cocaine, are blocked by the glucocorticoid receptor antagonist RU486. These results suggest that plasticity at excitatory synapses on dopamine neurons may be a key neural adaptation contributing to addiction and its interactions with stress and thus may be an attractive therapeutic target for reducing the risk of addiction. |
| Document Type: Article |
| Language: English |
| Reprint Address: Malenka, RC (reprint author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Palo Alto, CA 94304 USA |
Addresses:
1. Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Palo Alto, CA 94304 USA
2. Univ Calif San Francisco, Dept Neurol, Ernest Gallo Clin & Res Ctr, San Francisco, CA 94110 USA
3. Univ Calif San Francisco, Wheeler Ctr Neurobiol Addict, San Francisco, CA 94110 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Neurosciences |
| IDS Number: 648EH |
| ISSN: 0896-6273 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |