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| The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis |
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| Author(s): Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu HY, Pinto S, Colmers WF, Cone RD, Horvath TL |
| Source: NEURON Volume: 37 Issue: 4 Pages: 649-661 Published: FEB 20 2003 |
| Times Cited: 430 References: 62 |
| Abstract: The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized group of neurons adjacent to the third ventricle between the dorsal, ventral, paraventricular, and arcuate hypothalamic nuclei. These neurons send efferents onto key hypothalamic circuits, including those producing neuropeptide Y (NPY), Agouti-related protein (AGRP), proopiomelanocortin (POMC) products, and corticotropin-releasing hormone (CRH). Within the hypothalamus, ghrelin bound mostly on presynaptic terminals of NPY neurons. Using electrophysiological recordings, we found that ghrelin stimulated the activity of arcuate NPY neurons and mimicked the effect of NPY in the paraventricular nucleus of the hypothalamus (PVH). We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis. |
| Document Type: Article |
| Language: English |
| Reprint Address: Horvath, TL (reprint author), Yale Med Sch, Dept Obstet & Gynecol, New Haven, CT 06520 USA |
Addresses:
1. Yale Med Sch, Dept Obstet & Gynecol, New Haven, CT 06520 USA
2. Yale Med Sch, Dept Neurobiol, New Haven, CT 06520 USA
3. Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97201 USA
4. Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Neurosci, Beaverton, OR 97006 USA
5. Baylor Coll Med, Huffington Ctr Aging, Houston, TX 77030 USA
6. German Inst Human Nutr, D-14558 Bergholz Rehbrucke, Germany
7. Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
8. Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2H7 Canada
9. Innenstadt Univ Hosp, Neuroendocrine Labs, D-80336 Munich, Germany
10. CSIC, Inst Cajal, E-28002 Madrid, Spain
11. Rhode Isl Hosp, Brown Med Sch, Dept Med, Div Endocrinol, Providence, RI 02903 USA
12. Szent Istvan Univ, Fac Vet Med, Dept Anat & Histol, H-1078 Budapest, Hungary
13. Rockefeller Univ, Dept Mol Genet, New York, NY 10021 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Neurosciences |
| IDS Number: 648EH |
| ISSN: 0896-6273 |
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