| | |  | | | | Record from Web of Science® | | | | | | |
| Effect of pegylation on pharmaceuticals |
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| Author(s): Harris JM, Chess RB |
| Source: NATURE REVIEWS DRUG DISCOVERY Volume: 2 Issue: 3 Pages: 214-221 Published: MAR 2003 |
| Times Cited: 451 References: 74 |
| Abstract: Protein and peptide drugs hold great promise as therapeutic agents. However, many are degraded by proteolytic enzymes, can be rapidly cleared by the kidneys, generate neutralizing antibodies and have a short circulating half-life. Pegylation, the process by which polyethylene glycol chains are attached to protein and peptide drugs, can overcome these and other shortcomings. By increasing the molecular mass of proteins and peptides and shielding them from proteolytic enzymes, pegylation improves pharmacokinetics. This article will review how PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance. |
| Document Type: Review |
| Language: English |
| Reprint Address: Harris, JM (reprint author), Nektar Therapeut, 490 Discovery Dr, Huntsville, AL 35806 USA |
Addresses:
1. Nektar Therapeut, Huntsville, AL 35806 USA
2. Nektar Therapeut, San Carlos, CA 94070 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Biotechnology & Applied Microbiology; Pharmacology & Pharmacy |
| IDS Number: 649HM |
| ISSN: 1474-1776 |
| DOI: 10.1038/nrd1033 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |