| | |  | | | | Record from Web of Science® | | | | | | |
| Laboratory acquired infection with recombinant vaccinia virus containing an immunornodulating construct |
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| Author(s): Mempel M, Isa G, Klugbauer N, Meyer H, Wildi G, Ring J, Hofmann F, Hofmann H |
| Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 120 Issue: 3 Pages: 356-358 Published: MAR 2003 |
| Times Cited: 10 References: 16 |
| Abstract: Handling of Vaccinia virus represents a risk for laboratory-acquired infections, especially in individuals without completed vaccination. We report the case of a Vaccinia infection in a previously vaccinated researcher working with various genetically modified strains. We could confirm the infection by electron microscopy, positive cell culture, virus-specific PCR, sequence analysis, and viral neutralization test. The isolated virus carried a functionally inactivated cytohesin-1 gene of human origin, which had been shown to impair leukocyte adhesion by interacting with the LFA/ICAM-1 axis. The immunomodulating nature of the inserted construct might thus have added to the infectivity of the virus. We emphasize on the necessity of Vaccinia vaccination in laboratory staff working in the field.
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| Document Type: Article |
| Language: English |
| Reprint Address: Hofmann, H (reprint author), Tech Univ Munich, Klin & Poliklin Dermatol & Allergol Biederstein, Biedersteiner Str 29, D-80802 Munich, Germany |
Addresses:
1. Tech Univ Munich, Klin & Poliklin Dermatol & Allergol Biederstein, D-80802 Munich, Germany
2. Tiergesundheitsdienst Grub, Poing, Germany
3. Tech Univ Munich, Inst Pharmakol & Toxikol, Munich, Germany
4. German Armed Forces Med Acad, Inst Microbiol, Munich, Germany |
| Publisher: BLACKWELL PUBLISHING INC, 350 MAIN ST, MALDEN, MA 02148 USA |
| Subject Category: Dermatology |
| IDS Number: 651UG |
| ISSN: 0022-202X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |