| | |  | | | | Record from Web of Science® | | | | | | |
| Links between signal transduction, transcription and adhesion in epithelial bud development |
|
|
| Author(s): Jamora C, DasGupta R, Kocieniewski P, Fuchs E |
| Source: NATURE Volume: 422 Issue: 6929 Pages: 317-322 Published: MAR 20 2003 |
| Times Cited: 213 References: 29 |
| Abstract: The morphogenesis of organs as diverse as lungs, teeth and hair follicles is initiated by a downgrowth from a layer of epithelial stem cells(1,2). During follicular morphogenesis, stem cells form this bud structure by changing their polarity and cell-cell contacts. Here we show that this process is achieved through simultaneous receipt of two external signals: a Writ protein to stabilize beta-catenin, and a bone morphogenetic protein (BMP) inhibitor to produce Lef1. beta-Catenin then binds to, and activates, Lef1 transcription complexes that appear to act uncharacteristically by downregulating the gene encoding E-cadherin, an important component of polarity and intercellular adhesion. When either signal is missing, functional Lef1 complexes are not made, and E-cadherin downregulation and follicle morphogenesis are impaired. In Drosophila, E-cadherin can influence the plane of cell division and cytoskeletal dynamics(3). Consistent with this notion, we show that forced elevation of E-cadherin levels block invagination and follicle production. Our findings reveal an intricate molecular programme that links two extracellular signalling pathways to the formation of a nuclear transcription factor that acts on target genes to remodel cellular junctions and permit follicle formation. |
| Document Type: Article |
| Language: English |
| Reprint Address: Fuchs, E (reprint author), Rockefeller Univ, Howard Hughes Med Inst, Lab Mammalian Cell Biol & Dev, 1230 York Ave, New York, NY 10021 USA |
Addresses:
1. Rockefeller Univ, Howard Hughes Med Inst, Lab Mammalian Cell Biol & Dev, New York, NY 10021 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 656XX |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature01458 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |