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| Apoptosis-mediated cell death within the ovarian polar cell lineage of Drosophila melanogaster |
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| Author(s): Besse F, Pret AM |
| Source: DEVELOPMENT Volume: 130 Issue: 5 Pages: 1017-1027 Published: MAR 2003 |
| Times Cited: 18 References: 46 |
| Abstract: Polar cells have been described as pairs of specific follicular cells present at each pole of Drosophila egg chambers. They are required at different stages of oogenesis for egg chamber formation and establishment of both the anteroposterior and planar polarities of the follicular epithelium. We show that definition of polar cell pairs is a progressive process since early stage egg chambers contain a cluster of several polar cell marker-expressing cells at each pole, while as of stage 5, they contain invariantly two pairs of such cells. Using cell lineage analysis, we demonstrate that these pre-polar cell clusters have a polyclonal. origin and derive specifically from the polar cell lineage, rather than from that giving rise to follicular cells. In addition, selection of two polar cells from groups of pre-polar cells occurs via an apoptosis-dependent mechanism and is required for correct patterning of the anterior follicular epithelium of vitellogenic egg chambers. |
| Document Type: Article |
| Language: English |
| Reprint Address: Pret, AM (reprint author), Univ Paris 06, Inst Jacques Monod, UMR 7592 CNRS, Lab Genet Dev & Evolut, 2-4 Pl Jussieu, F-75251 Paris 05, France |
Addresses:
1. Univ Paris 06, Inst Jacques Monod, UMR 7592 CNRS, Lab Genet Dev & Evolut, F-75251 Paris 05, France |
| Publisher: COMPANY OF BIOLOGISTS LTD, BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND |
| Subject Category: Developmental Biology |
| IDS Number: 657UM |
| ISSN: 0950-1991 |
| DOI: 10.1242/dev.00313 |
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