| | |  | | | | Record from Web of Science® | | | | | | |
| Neurotrophins and their receptors: A convergence point for many signalling pathways |
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| Author(s): Chao MV |
| Source: NATURE REVIEWS NEUROSCIENCE Volume: 4 Issue: 4 Pages: 299-309 Published: APR 2003 |
| Times Cited: 378 References: 152 |
| Abstract: The neurotrophins are a family of proteins that are essential for the development of the vertebrate nervous system. Each neurotrophin can signal through two different types of cell surface receptor - the Trk receptor tyrosine kinases and the p75 neurotrophin receptor. Given the wide range of activities that are now associated with neurotrophins, it is probable that additional regulatory events and signalling systems are involved. Here, I review recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels. |
| Document Type: Review |
| Language: English |
| Reprint Address: Chao, MV (reprint author), NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA |
Addresses:
1. NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Neurosciences |
| IDS Number: 663TG |
| ISSN: 1471-0048 |
| DOI: 10.1038/nrn1078 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |