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Cell division
Author(s): Scholey JM, Brust-Mascher I, Mogilner A
Source: NATURE    Volume: 422    Issue: 6933    Pages: 746-752    Published: APR 17 2003  
Times Cited: 121     References: 79     
Abstract: In creating the mitotic spindle and the contractile ring, natural selection has engineered fascinating precision machines whose movements depend upon forces generated by ensembles of cytoskeletal proteins. These machines segregate chromosomes and divide the cell with high fidelity. Current research on the mechanisms and regulation of spindle morphogenesis, chromosome motility and cytokinesis emphasizes how ensembles of dynamic cytoskeletal polymers and multiple motors cooperate to generate the forces that guide the cell through mitosis and cytokinesis.
Document Type: Review
Language: English
Reprint Address: Scholey, JM (reprint author), Univ Calif Davis, Ctr Genet & Dev, Lab Cell & Computat Biol, Davis, CA 95616 USA
Addresses:
1. Univ Calif Davis, Ctr Genet & Dev, Lab Cell & Computat Biol, Davis, CA 95616 USA
Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Subject Category: Multidisciplinary Sciences
IDS Number: 668CG
ISSN: 0028-0836
DOI: 10.1038/nature01599
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