| | |  | | | | Record from Web of Science® | | | | | | |
| bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila |
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| Author(s): Brennecke J, Hipfner DR, Stark A, Russell RB, Cohen SM |
| Source: CELL Volume: 113 Issue: 1 Pages: 25-36 Published: APR 4 2003 |
| Times Cited: 520 References: 66 |
| Abstract: Cell proliferation, cell death, and pattern formation are coordinated in animal development. Although many proteins that control cell proliferation and apoptosis have been identified, the means by which these effectors are linked to the patterning machinery remain poorly understood. Here, we report that the bantam gene of Drosophila encodes a 21 nucleotide microRNA that promotes tissue growth. bantam expression is temporally and spatially regulated in response to patterning cues. bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity. |
| Document Type: Article |
| Language: English |
| Reprint Address: Cohen, SM (reprint author), European Mol Biol Lab, Meyerhofstr 1, D-69117 Heidelberg, Germany |
Addresses:
1. European Mol Biol Lab, D-69117 Heidelberg, Germany |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 668GX |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |