| | |  | | | | Record from Web of Science® | | | | | | |
| T cell anergy |
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| Author(s): Schwartz RH |
| Source: ANNUAL REVIEW OF IMMUNOLOGY Volume: 21 Pages: 305-334 Published: 2003 |
| Times Cited: 428 References: 121 |
| Abstract: T cell anergy is a tolerance mechanism in which the lymphocyte is intrinsically functionally inactivated following an antigen encounter, but remains alive for an extended period of time in a hyporesponsive state. Models of T cell anergy affecting both CD4(+) and CD8(+) cells fall into two broad categories. One, clonal anergy, is principally a growth arrest state, whereas the other, adaptive tolerance or in vivo anergy, represents a more generalized inhibition of proliferation and effector functions. The former arises from incomplete T cell activation, is mostly observed in previously activated T cells, is maintained by a block in the Ras/MAP kinase pathway, can be reversed by IL-2 or anti-OX40 signaling, and usually does not result in the inhibition of effector functions. The latter is most often initiated in naive T cells in vivo by stimulation in an environment deficient in costimulation or high in coinhibition. Adaptive tolerance can be induced in the thymus or in the periphery. The cells proliferate and differentiate to varying, degrees and then downregulate both functions in the face of persistent antigen. The state involves an early block in tyrosine kinase activation, which predominantly inhibits calcium mobilization, and an independent mechanism that blocks signaling through the IL-2 receptor. Adaptive tolerance reverses in the absence of antigen. Aspects of both of the anergic states are found in regulatory T cells, possibly preventing them from dominating initial immune responses to foreign antigens and shutting down such responses prematurely. |
| Document Type: Review |
| Language: English |
| Reprint Address: Schwartz, RH (reprint author), NIH, Cellular & Mol Immunol Lab, Bldg 10, Bethesda, MD 20892 USA |
Addresses:
1. NIH, Cellular & Mol Immunol Lab, Bethesda, MD 20892 USA |
| Publisher: ANNUAL REVIEWS, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA |
| Subject Category: Immunology |
| IDS Number: 672MB |
| ISSN: 0732-0582 |
| DOI: 10.1146/annurev.immunol.21.120601.141110 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |