| | |  | | | | Record from Web of Science® | | | | | | |
| Sphingosine-1-phosphate: An enigmatic signalling lipid |
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| Author(s): Spiegel S, Milstien S |
| Source: NATURE REVIEWS MOLECULAR CELL BIOLOGY Volume: 4 Issue: 5 Pages: 397-407 Published: MAY 2003 |
| Times Cited: 598 References: 91 |
| Abstract: The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement. |
| Document Type: Review |
| Language: English |
| Reprint Address: Spiegel, S (reprint author), Virginia Commonwealth Univ, Dept Biochem, Med Coll Virginia Campus, Richmond, VA 23298 USA |
Addresses:
1. Virginia Commonwealth Univ, Dept Biochem, Richmond, VA 23298 USA
2. NIMH, Lab Cellular & Mol Regulat, Bethesda, MD 20892 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 675HB |
| ISSN: 1471-0072 |
| DOI: 10.1038/nrm1103 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |