| | |  | | | | Record from Web of Science® | | | | | | |
| Historical review: Mitochondria and calcium: ups and downs of an unusual relationship |
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| Author(s): Carafoli E |
| Source: TRENDS IN BIOCHEMICAL SCIENCES Volume: 28 Issue: 4 Pages: 175-181 Published: APR 2003 |
| Times Cited: 42 References: 52 |
| Abstract: The discovery of Ca2+ transport by mitochondria is conventionally credited to De Luca and Engstrom, and Vasington and Murphy, who showed in 1961-1962 that Ca2+ was taken up by isolated mitochondria using respiratory or ATIP energy. However, contributions had already appeared in the 1950s showing - albeit indirectly - that isolated mitochondria bound Ca2+ actively. Somehow, however, these contributions failed to attract the attention that they undoubtedly deserved. The 1961-1962 findings started the ball rolling, initiating a topic that was to have a peculiar oscillatory history. It went from peaks of great enthusiasm to valleys of essential neglect, and from there to a final (hopefully permanent) robust revival. |
| Document Type: Review |
| Language: English |
| Reprint Address: Carafoli, E (reprint author), Univ Padua, Dept Biochem, Viale G Colombo 3, I-35121 Padua, Italy |
Addresses:
1. Univ Padua, Dept Biochem, I-35121 Padua, Italy
2. Venetian Inst Mol Med VIMM, I-35129 Padua, Italy |
| Publisher: ELSEVIER SCIENCE LONDON, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: 677AC |
| ISSN: 0968-0004 |
| DOI: 10.1016/S0968-0004(03)00053-7 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |