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| HER2 oncogene amplification in extramammary Paget's disease |
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| Author(s): Tanskanen M, Jahkola T, Asko-Seljavaara S, Jalkanen J, Isola J |
| Source: HISTOPATHOLOGY Volume: 42 Issue: 6 Pages: 575-579 Published: JUN 2003 |
| Times Cited: 12 References: 21 |
| Abstract: Aims: To study HER2 oncogene amplification and over-expression in skin samples of 23 patients with extramammary Paget's disease (EMP). EMP is a rare intra-epidermal adenocarcinoma, which has been reported to over-express the HER2 oncoprotein. Methods and results: HER2 gene amplification, detected by chromogenic in-situ hybridization, was found in 43% (10/23) of the lesions. HER2 protein over-expression (3+ immunostaining intensity) was found in 12 tumours (52%), including all 10 tumours with gene amplification. Two tumours showed low-level (2+) HER2 immunostaining. Mammary Paget's lesions, which were used as controls, showed HER2 amplification and over-expression in all 10 cases studied.
Conclusions: These results indicate that HER-2 protein over-expression in EMP is common and due exclusively to gene amplification. They open up the possibility of HER2-targetted immunotherapy for patients with HER2+ disease.
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| Document Type: Article |
| Language: English |
| Reprint Address: Tanskanen, M (reprint author), Univ Helsinki, Haartman Inst, Dept Pathol, POB 21 Haartmaninkatu 3, FIN-00014 Helsinki, Finland |
Addresses:
1. Univ Helsinki, Haartman Inst, Dept Pathol, FIN-00014 Helsinki, Finland
2. Univ Helsinki, Cent Hosp, Dept Plast Surg, Helsinki, Finland
3. Univ Helsinki, Cent Hosp, Dept Obstet & Gynecol, FIN-00290 Helsinki, Finland
4. Tampere Univ, Inst Med Technol, FIN-33101 Tampere, Finland
5. Univ Hosp, Tampere, Finland |
| Publisher: BLACKWELL PUBLISHING LTD, 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND |
| Subject Category: Cell Biology; Pathology |
| IDS Number: 682BK |
| ISSN: 0309-0167 |
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