| | |  | | | | Record from Web of Science® | | | | | | |
| Killing the messenger: Short RNAs that silence gene expression |
|
|
| Author(s): Dykxhoorn DM, Novina CD, Sharp PA |
| Source: NATURE REVIEWS MOLECULAR CELL BIOLOGY Volume: 4 Issue: 6 Pages: 457-467 Published: JUN 2003 |
| Times Cited: 566 References: 113 |
| Abstract: Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies. |
| Document Type: Review |
| Language: English |
| Reprint Address: Sharp, PA (reprint author), MIT, Ctr Canc Res, 40 Ames St,E17-529, Cambridge, MA 02139 USA |
Addresses:
1. MIT, Ctr Canc Res, Cambridge, MA 02139 USA
2. MIT, Dept Biol, Cambridge, MA 02139 USA
3. MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 684RN |
| ISSN: 1471-0072 |
| DOI: 10.1038/nrm1129 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |