| | |  | | | | Record from Web of Science® | | | | | | |
| Gene transfer as a tool to induce therapeutic vascular growth |
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| Author(s): Yla-Herttuala S, Alitalo K |
| Source: NATURE MEDICINE Volume: 9 Issue: 6 Pages: 694-701 Published: JUN 2003 |
| Times Cited: 179 References: 110 |
| Abstract: Therapeutic induction of vascular growth may provide a treatment option for those patients with myocardial or peripheral ischemia who are not suited to conventional revascularization therapies. Some lymphatic vascular disorders may also be amenable to this therapy. However, clear evidence of efficacy must be obtained from phase 2 and 3 clinical trials before these new treatments can be entered into clinical practice. Apart from the clinical applications, gene transfer aimed at stimulating or blocking vascular growth with various growth factors, cytokines, transcription factors and receptors or their antagonists is useful for analyzing the effects of those molecules on the vasculature, especially when gene targeting results in lethality or when large animal models are required. |
| Document Type: Review |
| Language: English |
| Reprint Address: Yla-Herttuala, S (reprint author), Univ Kuopio, AI Virtanen Inst, POB 1627, FIN-70211 Kuopio, Finland |
Addresses:
1. Univ Kuopio, AI Virtanen Inst, FIN-70211 Kuopio, Finland
2. Univ Kuopio, Dept Med, FIN-70211 Kuopio, Finland
3. Kuopio Univ Hosp, Gene Therapy Unit, FIN-70211 Kuopio, Finland
4. Haartman Inst, Mol Canc Biol Lab, FIN-00014 Helsinki, Finland
5. Haartman Inst, Ludwig Inst Canc Res, FIN-00014 Helsinki, Finland
6. Univ Helsinki, Cent Hosp, Biomedicum Helsinki, FIN-00014 Helsinki, Finland |
| Publisher: NATURE PUBLISHING GROUP, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: 688PH |
| ISSN: 1078-8956 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |