| Modifier genes and protective alleles in humans and mice |
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| Author(s): Nadeau JH |
| Source: CURRENT OPINION IN GENETICS & DEVELOPMENT Volume: 13 Issue: 3 Pages: 290-295 Published: JUN 2003 |
| Times Cited: 45 References: 66 |
| Abstract: Interest in modifier genes is growing rapidly because of their ability to modulate the phenotype of individuals with monogenic and multigenic traits and diseases. A neglected class of modifiers is protective alleles that can suppress disease in otherwise susceptible individuals. Together these modifier genes and protective alleles provide important glimpses into the molecular and cellular basis for the functional networks that provide robustness and homeostasis in complex biological systems. |
| Document Type: Article |
| Language: English |
| Reprint Address: Nadeau, JH (reprint author), Case Western Reserve Univ, Dept Genet, 10900 Euclid Ave, Cleveland, OH 44106 USA |
Addresses:
1. Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA
2. Case Western Reserve Univ, Ctr Computat Genom, Cleveland, OH 44106 USA |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Cell Biology; Genetics & Heredity |
| IDS Number: 691AM |
| ISSN: 0959-437X |
| DOI: 10.1016/S0959-437X(03)00061-3 |