| | |  | | | | Record from Web of Science® | | | | | | |
| On the complete determination of biological systems |
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| Author(s): Selinger DW, Wright MA, Church GM |
| Source: TRENDS IN BIOTECHNOLOGY Volume: 21 Issue: 6 Pages: 251-254 Published: JUN 2003 |
| Times Cited: 24 References: 17 |
| Abstract: The nascent field of systems biology ambitiously proposes to integrate information from large-scale biology projects to create computational models that are, in some sense, complete. However, the details of what would constitute a complete systems-level model of an organism are far from clear. To provide a framework for this difficult question it is useful to define a model as a set of rules that maps a set of inputs (e.g. descriptions of the cell's environment) to a set of outputs (e.g. the concentrations of all its RNAs and proteins). We show how the properties of a model affect the required experimental sampling and estimate the number of experiments needed to 'complete' a particular model. Based on these estimates, we suggest that the complete determination of a biological system is a concrete, achievable goal. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: Church, GM (reprint author), Harvard Univ, Sch Med, Dept Genet, 200 Longwood Ave, Boston, MA 02115 USA |
Addresses:
1. Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA |
| Publisher: ELSEVIER SCIENCE LONDON, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Biotechnology & Applied Microbiology |
| IDS Number: 691TK |
| ISSN: 0167-7799 |
| DOI: 10.1016/S0167-7799(03)00113-6 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |