| | |  | | | | Record from Web of Science® | | | | | | |
| Transcription regulation and animal diversity |
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| Author(s): Levine M, Tjian R |
| Source: NATURE Volume: 424 Issue: 6945 Pages: 147-151 Published: JUL 10 2003 |
| Times Cited: 398 References: 74 |
| Abstract: Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrate genomes have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression. |
| Document Type: Review |
| Language: English |
| Reprint Address: Tjian, R (reprint author), Univ Calif Berkeley, Ctr Integrat Genom, Dept Mol & Cell Biol, Div Genet & Dev, 401 Barker Hall, Berkeley, CA 94720 USA |
Addresses:
1. Univ Calif Berkeley, Ctr Integrat Genom, Dept Mol & Cell Biol, Div Genet & Dev, Berkeley, CA 94720 USA
2. Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 699AA |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature01763 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |