| | |  | | | | Record from Web of Science® | | | | | | |
| Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans |
|
|
| Author(s): Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C |
| Source: NATURE Volume: 424 Issue: 6946 Pages: 277-284 Published: JUL 17 2003 |
| Times Cited: 488 References: 52 |
| Abstract: Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing of Caenorhabditis elegans in response to insulin/insulin-like growth factor 1 (IGF-I) signalling. Using DNA microarray analysis, we have found that DAF-16 affects expression of a set of genes during early adulthood, the time at which this pathway is known to control ageing. Here we find that many of these genes influence the ageing process. The insulin/IGF-I pathway functions cell non-autonomously to regulate lifespan, and our findings suggest that it signals other cells, at least in part, by feedback regulation of an insulin/IGF-I homologue. Furthermore, our findings suggest that the insulin/IGF-I pathway ultimately exerts its effect on lifespan by upregulating a wide variety of genes, including cellular stress-response, antimicrobial and metabolic genes, and by downregulating specific life-shortening genes. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kenyon, C (reprint author), Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA |
Addresses:
1. Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
2. Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
3. Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
4. Univ Cambridge, Wellcome CRC Inst, Cambridge CB2 1QR, England
5. Univ Cambridge, Dept Genet, Cambridge CB2 1QR, England |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 701RZ |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature01789 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |