| | |  | | | | Record from Web of Science® | | | | | | |
| Technicolour transgenics: Imaging tools for functional genomics in the mouse |
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| Author(s): Hadjantonakis AK, Dickinson ME, Fraser SE, Papaioannou VE |
| Source: NATURE REVIEWS GENETICS Volume: 4 Issue: 8 Pages: 613-625 Published: AUG 2003 |
| Times Cited: 74 References: 143 |
| Abstract: Over the past decade, a battery of powerful tools that encompass forward and reverse genetic approaches have been developed to dissect the molecular and cellular processes that regulate development and disease. The advent of genetically-encoded fluorescent proteins that are expressed in wild type and mutant mice, together with advances in imaging technology, make it possible to study these biological processes in many dimensions. Importantly, these technologies allow direct visual access to complex events as they happen in their native environment, which provides greater insights into mammalian biology than ever before. |
| Document Type: Review |
| Language: English |
| Reprint Address: Hadjantonakis, AK (reprint author), Columbia Univ Coll Phys & Surg, Dept Genet & Dev, 701 W 168th St, New York, NY 10032 USA |
Addresses:
1. Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA
2. CALTECH, Beckman Inst, Pasadena, CA 91125 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Genetics & Heredity |
| IDS Number: 707CF |
| ISSN: 1471-0056 |
| DOI: 10.1038/nrg1126 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |