| The interplay between the glucocorticoid receptor and nuclear factor-kappa B or activator protein-1: Molecular mechanisms for gene repression |
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| Author(s): De Bosscher K, Vanden Berghe W, Haegeman G |
| Source: ENDOCRINE REVIEWS Volume: 24 Issue: 4 Pages: 488-522 Published: AUG 2003 |
| Times Cited: 244 References: 782 |
| Abstract: The inflammatory response is a highly regulated physiological process that is critically important for homeostasis. A precise physiological control of inflammation allows a timely reaction to invading pathogens or to other insults without causing overreaction liable to damage the host. The cellular signaling pathways identified as important regulators of inflammation are the signal transduction cascades mediated by the nuclear factor-kappaB and the activator protein-1, which can both be modulated by glucocorticoids. Their use in the clinic includes treatment of rheumatoid arthritis, asthma, allograft rejection, and allergic skin diseases. Although glucocorticoids have been widely used since the late 1940s, the molecular mechanisms responsible for their antiinflammatory activity are still under investigation. The various molecular pathways proposed so far are discussed in more detail. |
| Document Type: Review |
| Language: English |
| Reprint Address: Haegeman, G (reprint author), State Univ Ghent, Dept Mol Biol, KL Ledeganckstr 35, B-9000 Ghent, Belgium |
Addresses:
1. State Univ Ghent, Dept Mol Biol, B-9000 Ghent, Belgium |
| Publisher: ENDOCRINE SOC, 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 USA |
| Subject Category: Endocrinology & Metabolism |
| IDS Number: 712PU |
| ISSN: 0163-769X |
| DOI: 10.1210/er.2002-0006 |